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Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT

Institute of Microbiology and Laboratory Medicine - Department of Research, Education, and Development

Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT

H.Hoffmann, K.Avsar, R.Göres, S.-C.Mavi, S.Hofmann-Thiel

Abstract

QuantiFERON-TB Gold IT analyses interferon-γ release from CD4+ T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8+ T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.

URL: https://www.sciencedirect.com/science/article/pii/S1198743X16301306

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