Larsson L., Corbett C., Kalmambetova G., Ahmedov S., Antonenka U., Iskakova A., Kadyrov A., Sahalchyk E., Kranzer K., Hoffmann H.
Drug susceptibility testing and its impact on RR/MDR-TB treatment decisions in the Kyrgyz Republic from 2017 to 2019. Int J Tuberc Lung Dis. In press

L. Larsson¹, C. Corbett¹, G. Kalmambetova, C. Utpatel, S. Ahmedov, U. Antonenka, A. Iskakova, A. Kadyrov, T.A. Kohl, V. Mohr, E. Sahalchyk, S. Niemann, H. Hoffmann¹, K. Kranzer¹
(¹equal contribution)
Whole-genome sequencing drug susceptibility testing is associated with positive MDR-TB treatment response. Int J Tuberc Lung Dis. In press

CRyPTIC Consortium
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach. Nat Commun. 12;15:488. doi: 10.1038/s41467-023-44325-5.

Joch M, Wojtas KP, Torres-Gómez H, Li Y, Meyer F, Straßburger M, Kerndl V, Dahse HM, Hertweck C, Hoffmann H, Görls H, Walter K, Hölscher C, Kloss F.
Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones. Eur J Med Chem. 15;264:116023. doi: 10.1016/j.ejmech.2023.116023.

Corbett C, Finger P, Heiß-Neumann M, Bohnert J, Eder IB, Eisele M, Friesen I, Kaasch AJ, Kehrmann J, Lang R, Rödel J, Roessler S, Schmidt A, Schneitler S, Schui D, Schuler F, Sedlacek L, Serr A, Sitaru AG, Steinmann J, Wagner D, Wichelhaus TA; EpiNTM-Group; Hofmann-Thiel S, Hoffmann H.
Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020. Emerg Microbes Infect.;12:2276342. doi: 10.1080/22221751.2023.2276342.

Schlanderer J, Hoffmann H, Lüddecke J, Golubov A, Grasse W, Kindler EV, Kohl TA, Merker M, Metzger C, Mohr V, Niemann S, Pilloni C, Plesnik S, Raya B, Shresta B, Utpatel C, Zengerle R, Beutler M, Paust N.
Two-stage tuberculosis diagnostics: combining centrifugal microfluidics to detect TB infection and Inh and Rif resistance at the point of care with subsequent antibiotic resistance profiling by targeted NGS. Lab Chip. 20;24:74-84. doi: 10.1039/d3lc00783a.

Köhler N, Karaköse H, Grobbel HP, Hillemann D, Andres S, König C, Kalsdorf B, Brehm TT, Böttcher L, Friesen I, Hoffmann H, Strelec D, Schaub D, Peloquin CA, Schmiedel S, Decosterd LA, Choong E, Wicha SG, Aarnoutse RE, Lange C, Sánchez Carballo PM 
A Single-Run HPLC-MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis. Pharmaceutics. 27;15:2543. doi: 10.3390/pharmaceutics15112543.

Lindsay Sonnenkalb, Joshua James Carter, Andrea Spitaleri, Zamin Iqbal, Martin Hunt, Kerri Marie Malone, Christian Utpatel, Daniela Maria Cirillo, Camilla Rodrigues, Kayzad Soli Nilgiriwala, Philip William Fowler, Matthias Merker, Stefan Niemann
Comprehensive Resistance Prediction for Tuberculosis: an International Consortium. Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis. Lancet Microbe;4:e358-e368. doi: 10.1016/S2666-5247(23)00002-2.

Corbett CS; Kalmambetova G; Umetalieva N; Ahmedov S; Antonenka U; Myrzaliev B; Sahalchyk E; Vogel M; Kadyrov A; Hoffmann H.
QuantiFERON-TB Gold plus testing for the detection of LTBI among health care workers in major TB hospitals of the Northern Kyrgyz Republic. BMC Infect Dis 22, 180 (2022). https://doi.org/10.1186/s12879-022-07149-0

Iris Finci, Audrey Albertini, Matthias Merker, Sönke Andres, Nino Bablishvili, Ivan Barilar, Tatiana Cáceres, Valeriu Crudu, Eduardo Gotuzzo, Nchimunya Hapeela, H. Hoffmann, Christine Hoogland, Thomas A Kohl, Katharina Kranzer, Anna Mantsoki, Florian P Maurer, Mark P Nicol, Ecaterina Noroc, Sara Plesnik, Timothy Rodwell, Morten Ruhwald, Theresa Savidge, Max Salfinger, Elizabeth Streicher, Nestani Tukvadze, Robin Warren, Widaad Zemanay, Anna Zurek, Stefan Niemann, Claudia M Denkinger
Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study. Lancet Microbe. 3:e672-e682. doi:10.1016/S2666-5247(22)00116-1.

Dreyer V, Mandal A, Dev P, Merker M, Barilar I, Utpatel C, Nilgiriwala K, Rodrigues C, Crook DW; CRyPTIC Consortium; Rasigade JP, Wirth T, Mistry N, Niemann S.
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region. Genome Med. 2022 Aug 22;14(1):95. doi: 10.1186/s13073-022-01076-0.

Shuaib YA, Utpatel C, Kohl TA, Barilar I, Diricks M, Ashraf N, Wieler LH, Kerubo G, Mesfin EA, Diallo AB, Al-Hajoj S, Ndung’u P, Fitzgibbon MM, Vaziri F, Sintchenko V, Martinez E, Viegas SO, Zhou Y, Azmy A, Al-Amry K, Godreuil S, Varma-Basil M, Narang A, Ali S, Beckert P, Dreyer V, Kabwe M, Bates M, Hoelscher M, Rachow A, Gori A, Tekwu EM, Sidze LK, Jean-Paul AA, Beng VP, Ntoumi F, Frank M, Diallo AG, Mboup S, Tessema B, Beyene D, Khan SN, Diel R, Supply P, Maurer FP, Hoffmann H, Niemann S, Merker M.
Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3. Genes (Basel); 13:990. doi: 10.3390/genes13060990.

The CRyPTIC Consortium.
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. PLoS Biol. 2022 Aug 9;20(8):e3001721. doi: 10.1371/journal.pbio.3001721. eCollection 2022 Aug. PMID: 35944069

Fowler PW, Wright C, Spiers H, Zhu T, Baeten EML, Hoosdally SW, Gibertoni Cruz AL, Roohi A, Kouchaki S, Walker TM, Peto TEA, Miller G, Lintott C, Clifton D, Crook DW, Walker AS; Zooniverse Volunteer Community; CRyPTIC Consortium.
A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates. Elife. 2022 May 19;11:e75046. doi: 10.7554/eLife.75046.

Walker TM, Miotto P, Köser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, Comas I, Posey J, Omar SV, Peto TE, Suresh A, Uplekar S, Laurent S, Colman RE, Nathanson CM, Zignol M, Walker AS; CRyPTIC Consortium ; Seq&Treat Consortium; Crook DW, Ismail N, Rodwell TC.
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis. Lancet Microbe. 2022 Apr;3(4):e265-e273. doi: 10.1016/S2666-5247(21)00301-3.

Antimycobacterial Susceptibility Testing Group.
Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment. Eur Respir J; 59: 2200166. https://doi.org/10.1183/13993003.00166-2022

Markus Beutler, Ana R. Homann, Marina Mihalic, Sara Plesnik, Laura Niebling, Martin Eckart, Vera Allerheiligen, Daniel Czurratis, Bhagwan Maharjan, Bhabana Shrestha, Nargiza Parpieva, Laziz Turaev, Zayniddin Sayfutdinov, Sabine Hofmann-Thiel, Wolfgang Grasse, Christoph Metzger-Boddien, Nils Paust, Hoffmann H.
Rapid Tuberculosis diagnostics including molecular first- and second-line resistance testing based on a novel microfluidic DNA extraction cartridge. J Mol Diagn. 23:643-650. doi: 10.1016/j.jmoldx.2021.02.004

Homann AR, Niebling L, Zehnle S, Beutler M, Eckart M, Czurratis D, Beller KD, Zengerle R, Hoffmann H, Paust N.
A microfluidic cartridge for fast and accurate diagnosis of Mycobacterium tuberculosis infections on standard laboratory equipment. Lab on a Chip. 20;21(8):1540-1548. doi: 10.1039/d1lc00035

Vogel M, Utpatel C, Corbett C, Kohl TA, Iskakova A, Ahmedov S, Antonenka U, Dreyer V, Ibrahimova A, Kamarli C, Kosimova D, Mohr V, Sahalchyk E, Sydykova M, Umetalieva N, Kadyrov A, Kalmambetova G, Niemann S, Hoffmann H.
Implementation of whole genome sequencing for tuberculosis diagnostics in a low-middle income, high MDR-TB burden country. Sci Rep;11:15333. doi: 10.1038/s41598-021-94297-z.

Grobbel HP, Merker M, Köhler N, Andres S, Hoffmann H, Heyckendorf J, Reimann M, Barilar I, Dreyer V, Hillemann D, Kalsdorf B, Kohl TA, Sanchez Carballo P, Schaub D, Todt K, Utpatel C, Maurer FP, Lange C, Niemann S.
Design of Multidrug-Resistant Tuberculosis Treatment Regimens Based on DNA Sequencing. Clin Infect Dis;73:1194-1202. doi: 10.1093/cid/ciab359.

de Vos M, Scott L, David A, Trollip A, Hoffmann H, Georghiou S, Carmona S, Ruhwald M, Stevens W, Denkinger CM, Schumacher SG.
Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid. J Clin Microbiol; 59(3):e02168-20. doi: 10.1128/JCM.02168-20.

Corbett C, Kulzhabaeva A, Toichkina T, Kalmambetova G, Ahmedov S, Antonenka U, Iskakova A, Kosimova D, Migunov D, Myrzaliev B, Sahalchyk E, Umetalieva N, Vogel M, Kadyrov A, Hoffmann H 
Implementing contact tracing for tuberculosis in Kyrgyz Republic and risk factors for positivity using QuantiFERON-TB Gold plus. BMC Infect Dis. 20:746. doi: 10.1186/s12879-020-05465-x.

Hofmann-Thiel S, Plesnik S, Mihalic M, Heiß-Neumann M, Avsar K, Beutler M, Hoffmann H.
Clinical Evaluation of BD MAX MDR-TB Assay for Direct Detection of Mycobacterium tuberculosis Complex and Resistance Markers. J Mol Diagn.;22(10):1280-1286. doi: 10.1016/j.jmoldx.2020.06.013. Epub 2020 Jul 17.

Beutler M, Plesnik S, Mihalic M, Olbrich L, Heinrich N, Schumacher S, Lindner M, Koch I, Grasse W, Metzger-Boddien C, Hofmann-Thiel S, Hoffmann H.
A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB. PLoS One.15:e0227215. doi: 10.1371/journal.pone.0227215. eCollection 2020.

Margaretha de Vos, Lesley Scott, Anura David, Andre Trollip, H. Hoffmann, Sophia Georghiou, Sergio Carmona, Morten Ruhwald, Wendy Stevens, Claudia M. Denkinger , Samuel G. Schumacher
Comparative analytical evaluation of four centralized platforms for the detection of M. tuberculosis complex and resistance to rifampicin and isoniazid. J Clin Microbiol. J Clin Microbiol.02168-20

Andres S, Merker M, Heyckendorf J, Kalsdorf B, Rumetshofer R, Indra A, Hofmann-Thiel S, Hoffmann H, Lange C, Niemann S, Maurer FP.
Bedaquiline-Resistant Tuberculosis: Dark Clouds on the Horizon. Am J Respir Crit Care Med. 201:1564-1568. doi: 10.1164/rccm.201909-1819LE.

Beckert P, Sanchez-Padilla E, Merker M, Dreyer V, Kohl TA, Utpatel C, Köser CU, Barilar I, Ismail N, Omar SV, Klopper M, Warren RM, Hoffmann H, Maphalala G, Ardizzoni E, de Jong BC, Kerschberger B, Schramm B, Andres S, Kranzer K, Maurer FP, Bonnet M, Niemann S.
Phenotypic bedaquiline and clofazimine resistant multidrug-resistant Mycobacterium tuberculosis outbreak strains in eSwatini in the pre-treatment era. Genome Medicine 12:104-114; GMED-D-20-00338R3

Wilson DJ; CRyPTIC Consortium
GenomegaMap: Within-Species Genome-Wide dN/dS Estimation from over 10,000 Genomes. Mol Biol Evol. 37(8):2450-2460. doi: 10.1093/molbev/msaa069.

Polsfuss S, Hofmann-Thiel S, Merker M, Krieger D, Niemann S, Rüssmann H, Schönfeld N, Hoffmann H, Kranzer K.
Emergence of low level delamanid and bedaquiline resistance during extremely drug resistant tuberculosis treatment. Clin Infect Dis; ciz074, https://doi.org/10.1093/cid/ciz074

Engström A, Antonenka U, Kadyrov A, Kalmambetova G, Kranzer K, Merker M, Kabirov O, Parpieva N, Rajabov A, Sahalchyk E, Sayfudtinov Z, Niemann S, Hoffmann H.
Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia. BMC Infect Dis. 29;19:908. doi: 10.1186/s12879-019-4480-7.

Daniel J Wilson, The CRyPTIC Consortium.
GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes. bioRxiv doi; https://doi.org/10.1101/523316

Hofmann-Thiel S, Molodtsov N, Antonenka U, Hoffmann H.
Capacity of Abbott RealTime MTB RIF/INH to detect rifampicin and isoniazid resistant tuberculosis. Int J Tubercul Lung Dis; 23:458-464

Yang Y, Walker TM, Walker AS, Wilson DJ, Peto TEA, Crook DW, Shamout F; CRyPTIC Consortium, Zhu T, Clifton DA.
DeepAMR for predicting co-occurrent resistance of Mycobacterium tuberculosis. Bioinformatics. 2019;35:3240-3249. doi: 10.1093/bioinformatics/btz067.

Kranzer K, Kalsdorf B, Heyckendorf J, Andres S, Merker M, Hofmann-Thiel S, Bloemberg GV, Hoffmann H, Niemann S, Lange C, Maurer FP.
New WHO Treatment Recommendations for Multidrug-Resistant Tuberculosis: Are We Well Enough Prepared? Am J Respir Crit Care Med; 2019. doi: 10.1164/rccm.201902-0260LE.

Karg O, Avsar K, Hoffmann H.
Sputum Gewinnung Schritt für Schritt. Pneumologie 72: 782-789

Philip W Fowler, PhD; Ana L Gibertoni Cruz; Sarah J Hoosdally; Lisa Jarrett; Emanuele Borroni; Matteo Chiacchiaretta; Priti Rathod; Sarah Lehmann; Nikolay Molodtsov; Timothy M Walker; Esther Robinson; Hoffmann H; Timothy EA Peto; Daniela M Cirillo; Grace E Smith; Derrick W Crook.
Automated detection of bacterial growth on 96-well plates for high-throughput drug susceptibility testing of Mycobacterium tuberculosis. Microbiology; 164:1522-1530

Timothy M Walker, Matthias Merker, Astrid Knoblauch, Peter Helbling, Otto Schoch, Marieke J. van der Werf, Katharina Kranzer, Lena Fiebig, Stefan Kröger, Walter Haas, Hoffmann H, Alexander Indra, Daniela M Cirillo, Jérôme Robert, Tomas R Rogers, , Ramona Groenheit, Anne T Mengshoel, Vanessa Mathys, Marjo Haanperä, Dick van Soolingen, Stefan Niemann, Erik C Böttger, Peter M Keller, and the MDR-TB Cluster Consortium.
Whole-genome sequencing facilitates an effective pan-European response to a cluster of MDR-TB in refugees from the Horn of Africa. The Lancet Infectious Diseases; 18:431-440

Maharjan B, Nakajima C, Isoda N, Thapa J, Poudel A, Shah Y, Yamaguchi T, Shrestha B, Hoffmann H, Avsar K, Shrestha A, Gordon SV, Suzuki Y.
Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal. Sci Rep.;8:16634. doi: 10.1038/s41598-018-34306-w.

Hoffmann H, Avsar K, Göres R, Mavi SC, Hofmann-Thiel S.
Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT. Clin Microbiol Infect; 22:701-3.

Hofmann-Thiel S, Molodtsov N, Antonenka U, Hoffmann H.
Evaluation of the Abbott RealTime MTB and RealTime MTB INH/RIF Assays for Direct Detection of Mycobacterium tuberculosis Complex and Resistance Markers in Respiratory and Extrapulmonary Specimens. J Clin Microbiol; 54:3022-3027

Hofmann-Thiel S, Hoffmann H, Hillemann D, Rigouts L, Van Deun A, Kranzer K.
How should discordance between molecular and growth-based assays for rifampicin resistance be investigated? Int J Tuberc Lung Dis; 21:721-726

van Leth F, Guenther G, Hoffmann H, Lange C
Reply from the Authors of Limited Benefit of the New Shorter MDR-TB Regimen in Europe. European MDR-TB database collaboration. Am J Respir Crit Care Med; doi: 10.1164/rccm.201705-0995LE

Engel M, Endesfelder D, Schloter-Hai B, Kublik S, Granitsiotis MS, Boschetto P, Stendardo M, Barta I, Dome B, Deleuze JF, Boland A, Müller-Quernheim J, Prasse A, Welte T, Hohlfeld J, Subramanian D, Parr D, Gut IG, Greulich T, Koczulla AR, Nowinski A, Gorecka D, Singh D, Gupta S, Brightling CE, Hoffmann H, Frankenberger M, Hofer TP, Burggraf D, Heiss-Neumann M, Ziegler-Heitbrock L, Schloter M, Zu Castell W.
Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome. PLoS One; 12:e0180859.

Lange B, Khan P, Kalmambetova G, Al-Darraji H, Alland D, Antonenka U, Brown T, Balcells ME, Blakemore R, Denkinger CM, Dheda K, Hoffmann H, Kadyrov A, Lemaitre N, Miller MB, Nikolayevskyy V, Ntinginya EN, Ozkutuk N, Palacios JJ, Popowitch EB, Porcel JM, Teo J, Theron G, Kranzer K.
Diagnostic accuracy of the Xpert® MTB/RIF cycle threshold level to predict smear positivity: a meta-analysis. Int J Tubercul Lung Dis; 21:493-502

Hoffmann H, Kohl T, Sabine Hofmann-Thiel, Merker M, Beckert P, Jaton K, Nedialkova L, Sahalchyk E, Rothe T, Keller PM, Niemann S.
Delamanid and Bedaquiline resistance in Mycobacterium tuberculosis ancestral Beijing genotype causing XDR-TB in a Tibetian refugee. Am J Resp Crit Care Med. 193:337-340

Hoffmann H, Borroni E, Schena E, Nedialkova L, Hofmann-Thiel S, Cirillo D.
Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system-authors‘ response. J Antimicrob Chemother.;71:3625. doi: 10.1093/jac/dkw365.

Schena E, Nedialkova L, Borroni E, Battaglia S, Cabibbe AM, Niemann S, Utpatel C, Merker M, Trovato A, Hofmann-Thiel S, Hoffmann H (equal contributing last author), Cirillo DM.
Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system. J Antimicrob Chemother; doi: 10.1093/jac/dkw044

Armin Zittermann, Stefan Pilz, Hoffmann H, Winfried März.
Vitamin D and airway infections: a European perspective. European Journal of Medical Research 21:14

Wassilew N, Hoffmann H, Andrejak C, Lange C.
Pulmonary Disease Caused by Non-Tuberculous Mycobacteria (Review). Respiration; 91:386-402

Hofmann-Thiel S, Hoffmann H.
Evaluation of Fluorotype MTB for detection of Mycobacterium tuberculosis complex DNA in clinical specimens from a low-incidence country. BMC Infectious Diseases 14:59

Zignol M, Masoud D, Dean A, Falzon D, Dadu A, Kremer K, Hoffmann H, Hoffner S, Floyd K.
Drug-resistant tuberculosis in the WHO European Region: an analysis of surveillance data. Drug Resistance Update; 16:108-15

Frankenberger M, Ekici AB, Angstwurm MW, Hoffmann H, Hofer TP, Heimbeck I, Meyer P, Lohse P, Wjst M, Häussinger K, Reis A, Ziegler-Heitbrock L.
A defect of CD16-positive monocytes can occur without disease. Immunobiology. 218:169-74.

Hoefsloot W, van Ingen J, Andrejak C, Angeby K, Bauriaud R, Bemer P, Beylis N, Boeree MJ, Cacho J, Chihota V, Chimara E, Churchyard G, Cias R, Dasa R, Daley CL, Dekhuijzen PN, Domingo D, Drobniewski F, Esteban J, Fauville-Dufaux M, Folkvardsen DB, Gibbons N, Gómez-Mampaso E, Gonzalez R, Hoffmann H, Hsueh PR, Indra A, Jagielski T, Jamieson F, Jankovic M, Jong E, Keane J, Koh WJ, Lange B, Leao S, Macedo R, Mannsåker T, Marras TK, Maugein J, Milburn HJ, Mlinkó T, Morcillo N, Morimoto K, Papaventsis D, Palenque E, Paez-Peña M, Piersimoni C, Polanová M, Rastogi N, Richter E, Ruiz-Serrano MJ, Silva A, da Silva MP, Simsek H, van Soolingen D, Szabó N, Thomson R, Fernandez MT, Tortoli E, Totten SE, Tyrrell G, Vasankari T, Villar M, Walkiewicz R, Winthrop K, Wagner D; for NTM-NET (www.ntm-net.org).
The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study. Eur Respir J; 42:1604-13

Uladzimir Antonenka, Sabine Hofmann-Thiel, Laziz Turaev, Ainura Esenalieva, Mokhonim Abdullaeva, Evgeni Sahalchyk, Tarig Alnour and Hoffmann H.
Comparison of Xpert MTB/RIF with ProbeTec ET DTB and COBAS TaqMan MTB for direct detection of M. tuberculosis complex in respiratory specimens. BMC Infectious Diseases; 13:280

Beissner M, Piten E, Maman I, Symank D, Jansson M, Nitschke J, Amekuse K, Kobara B, Wiedemann F, Hoffmann H, Diefenhardt A, Badziklou K, Banla Kere A, Löscher T, Bretzel G.
Spontaneous Clearance of a Secondary Buruli Ulcer Lesion Emerging Ten Months after Completion of Chemotherapy – a Case Report from Togo. PloS NTD 6:e1747 pp1-7

Frankenberger M, Ekici AB, Angstwurm MW, Hoffmann H, Hofer TPJ, Heimbeck I, Meyer P, Lohse P, Wjst M, Häussinger K, Reis A, Ziegler-Heitbrock L.
A defect of CD16-positive Monocytes can occur without disease. Immunobiology 218:169

Kremer A., Hoffmann H.
Prevalences of the Enterobacter cloacae complex and its phylogenetic derivatives in the nosocomial environment. Eur J Clin Microbiol Infect Dis. 31:2951-2955

Kremer A., Hoffmann H.
Subtractive hybridization yields silver resistance determinant as unique to nosocomial pathogen in the Enterobacter cloacae complex. J Clin Microbiol 50:3249-3257

Bedenić B, Vraneš J, Hofmann-Thiel S, Tonkić M, Novak A, Bučević-Popovic V, Hoffmann H.
Characterization of the extended-spectrum β-lactamases and determination of the virulence factors of uropathogenic Escherichia coli strains isolated from children. Wien Klin Wochenschr.. 124:504-15.

Hofmann-Thiel S, Turaev L, Alnour T, Drath L, Mullerova M, Hoffmann H.
Multi-centre evaluation of the speed-oligo Mycobacteria assay for differentiation of Mycobacterium spp. in clinical isolates. BMC Infect Dis. 19;11:353.

Hofmann-Thiel S, Turaev L, Hoffmann H.
Evaluation of the hyplex TBC PCR test for detection of Mycobacterium tuberculosis complex in clinical samples. BMC Microbiol. 31:95.

Hofmann-Thiel S, van Ingen J, Feldmann K, Turaev L, Uzakova GT, Murmusaeva G, van Soolingen D, Hoffmann H.
Mechanisms of Heteroresistance to Isoniazid and Rifampin of M. tuberculosis in Tashkent, Uzbekistan. Eur Respir J. 33:368-74

Stefan Holdenrieder, Joachim von Pawel, Elke Dankelmann, Thomas Duell, Bernhard Faderl, Andreas Markus, Maria Siakavara, Horst Wagner, Knut Feldmann, Hoffmann H, Hannelore Raith, Dorothea Nagel, Petra Stieber.
Nucleosomes and CYFRA 21-1 indicate tumor response after one cycle of chemotherapy in recurrent non-small cell lung cancer. Lung Cancer 63:128-35.

Sebastian D. Schuck, Henrik Mueller, Frank Kunitz, Albert Neher, Hoffmann H, Kees L.C.M. Franken, Dirk Repsilber, Tom H. M. Ottenhoff, Stefan H. E. Kaufmann, and Marc Jacobsen. Identification of T-cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection. PloS ONE 2009;4(5):e5590.

Giovanni Battista Migliori, Barbara Eker, Morgan D’Arcy Richardson, Giovanni Sotgiu, Jean-Pierre Zellweger, Alena Skrahina, Johannes Ortmann, Enrico Girardi, Hoffmann H, Giorgio Besozzi, Nazario Bevilacqua, Detlef Kirsten, Rosella Centis and Christoph Lange for the TBNET Study Group.
Safety, tolerability and efficacy of linezolid in the treatment of MDR- and XDR-TB. A TBNET survey. Eur Resp J. 34:387-93.

Walter E-U, Allerheiligen V, Beer J, Binder L, Daeschlein G, Drath L, Kirschner P, Klotz M, Kunert U, Mauch H, Naumann L, Richter E, Schulz E, Hoffmann H im Auftrag des Arbeitskreis Mykobakterien (AKM).
Auszug aus der neuen DIN 58943-32 „Mikroskopische Methoden“ der Reihe „Tuberkulose- und Mykobakteriendiagnostik. Der Mikrobiologe 19:65-66

Drath L, Allerheiligen V, Beer J, Binder L, Daeschlein G, Kirschner P, Klotz M, Kunert U, Mauch H, Naumann L, Richter E, Schulz E, Walter E-U, Hoffmann H im Auftrag des Arbeitskreis Mykobakterien (AKM).
Übersicht der Neufassung der DIN 58943-3 „Kulturelle Methoden zum Nachweis von Mykobakterien“ der Reihe „Tuberkulose- und Mykobakteriendiagnostik. Der Mikrobiologe 19:61-62

Richter E, Allerheiligen V, Beer J, Binder L, Daeschlein G, Drath L, Kirschner P, Klotz M, Kunert U, Mauch H, Naumann L, Schulz E, Walter E-U, Hoffmann H im Auftrag des Arbeitskreis Mykobakterien (AKM).
Auszug aus der neuen DIN 58943-5 „Molekularbiologische Differenzierung von Tuberkulosebakterien“ der Reihe „Tuberkulose- und Mykobakteriendiagnostik. Der Mikrobiologe 19:63-64

Van Deun A, Barrera L, Bastian I, Fattorini L, Hoffmann H, Kam KM, Rigouts L, Rüsch-Gerdes S, Wright A.
Mycobacterium tuberculosis strains with highly discordant rifampin susceptibility test results. J Clin Microbiol. 47:3501-6

Hoffmann H, Reischl U.
TB or not TB. Mit der Einführung der PCR ist die Tuberkuloseidagnostik wesentlich einfacher, sensitiver und schneller geworden. Trillium report 7: 198

Richard Zaleskis, Gombogaram Tsogt, Andrei Dadu, Stefan Talevski, Kai Blondal, Hoffmann H, Maria Idrissova,
WHO / UNDP REVIEW OF THE TUBERCULOSIS CONTROL IN THE REPUBLIC OF TAJIKISTAN. WHO Geneva

Migliori GB, Sotgiu G, D‘Arcy Richardson M, Centis R, Guenther G, Hoffmann H, Cirillo DM, Toungossova O, Kliiman K, De Lorenzo S, Spanevello A, Lange C;
Tuberculosis Network European Trialsgroup. Consensus not yet reached on key drugs for extensively drug-resistant tuberculosis treatment. Clin Infect Dis. 49:315-6

I. Dubrovina, K. Miskinis, S. Lyepshina, Y. Yann, Hoffmann H, R. Zaleskis, P. Nunn, M. Zignol.
Drug-resistant tuberculosis and HIV in Ukraine: a threatening convergence of two epidemics? Int J Tuberc Lung Dis 12:756–762

Barbara Eker, Johannes Ortmann, Giovanni B. Migliori, Giovanni Sotgiu, Ralf Muetterlein, Rosella Centis, Hoffmann H, Detlef Kirsten, Tom Schaberg, Sabine Ruesch-Gerdes, and Christoph Lange, ort he German TBNET Group.
Multidrug- and extensively drug-resistant tuberculosis, Germany. Emerg Infect Dis 14:1700-6.

Giovanni Battista Migliori, Christoph Lange, Rosella Centis, Giovanni Sotgiu, Ralf Mütterlein, Hoffmann H, Kai Kliiman, Giuseppina De Iaco, Francesco Lauria, M. D’Arcy Richardson, Antonio Spanevello, Daniela M. Cirillo and TBNET Study Group,
Resistance to second-line injectable anti-TB drugs and treatment outcomes in MDR-TB and XDR-TB cases. Eur Resp J. 31:1155-9.

Stefan Holdenrieder, Joachim von Pawel, Elke Dankelmann, Thomas Duell, Bernhard Faderl, Andreas Markus, Maria Siakavara, Horst Wagner, Knut Feldmann, Hoffmann H, Hannelore Raith, Dorothea Nagel, Petra Stieber.
Nucleosomes, proGRP, NSE, CYFRA 21-1, and CEA in monitoring first line chemotherapy of small cell lung cancer. Clinical Cancer Research 14:7813-21.

Hoffmann H, Wenn das Licht ausgeht. Tuberkulosediagnostik in Usbekistan. news@micro.
Informationen für Mitarbeiter/innen der Carl Zeiss MicroImaging GmbH

Hoffmann H, Loytved G, Bodmer T.
Interferon-gamma release assays in tuberculosis diagnostics. Der Internist 48:497-506.

Klotz M, Binder L, Beer J, Drath L, Hoffmann H und der Arbeitskreis Mykobakterien (AKM).
Auszüge aus dem Entwurf der neuen DIN 58943-4 „Präanalytik in der Tuberkulose- und Mykobakteriendiagnostik“. Der Mikrobiologe 17:79-81

Hoffmann H
Standards der mikrobiologischen Diagnostik von „aktiver“ Tuberkulose in Deutschland. Atemwegs- und Lungenkrankheiten 9:382-392

S. Wegerle, A. Markus, N. Weber, H. Steffen, B. King, W. Eder, E. Philipp, A. Morresi-Hauff, K. Häußinger, Hoffmann H.
Pulmonale Nokardiose mit Trimethoprim/Sulfamethoxazol resistenter Nocardia paucivorans bei einem Patienten ohne Hinweise auf Immunsuppression. Pneumologie 61:46-51

Hoffmann H, Sibylle Stindl, Anita Stumpf, Andre Mehlen, Daniel Monget, Jürgen Heesemann, Karl H. Schleifer, Andreas Roggenkamp.
Description of Enterobacter ludwigii sp. Nov., a novel Enterobacter species of clinical relevance. Syst Appl Microbiol. 28 :206-212

Hoffmann H, Sibylle Stindl, Wolfgang Ludwig, Anita Stumpf, André Mehlen, Jürgen Heesemann, Daniel Monget, Karl H. Schleifer, Andreas Roggenkamp.
Reassignment of Enterobacter dissolvens to Enterobacter cloacae as E. cloacae subspecies dissolvens comb. Nov. and emended description of Enterobacter asburiae and Enterobacter kobei. Syst Appl Microbiol. 28 :196-205

Hoffmann H, Sibylle Stindl, Wolfgang Ludwig, Anita Stumpf, Andre Mehlen, Daniel Monget, Denis Pierard, Stefan Ziesing, Jürgen Heesemann, Andreas Roggenkamp, Karl H. Schleifer. Enterobacter hormaechei subspecies oharae subsp. Nov., E. hormaechei subspecies hormaechei subsp. Nov. And E. hormaechei subspecies steigerwaltii subsp. Nov., three new subspecies of clinical importance. J. Clin Microbiol. 43:3297-303

Anita N. Stumpf, Andreas Roggenkamp, Hoffmann H.
Specificity of ERIC- and REP-PCR for the detection of clonality within the Enterobacter cloacae complex. Diagn. Microbiol. Infect. Dis. 53, 9-16.

Hoffmann H, Sabine Schmoldt, Konrad Trülzsch, Anita Stumpf, Stefan Bengsch, Thomas Blankenstein, and Andreas Roggenkamp.
Nosocomial uro-sepsis caused by Enterobacter kobei with aberrant phenotype. Diagn. Microbiol. Infect. Dis. 53:143-7

Hoffmann H, Andreas Roggenkamp.
Prevalence of Extended Spectrum Betalactamases in isolates of the Enterobacter cloacae complex in German hospitals. Clin. Microbiol. Infect. 12:322-30.

Roggenkamp, A., Hoffmann H, Hornef, M.
Growth control of small-colony-variants by genetic regulation of hemin uptake system. Infect Immun 72, 2254-2262

Roggenkamp, A., Haas, A., Eder, W., Kreuzer, E., Hoffmann H.
Metabolically deficient methicillin-resistant Staphylococcus aureus as cuase of chronic post-thoracotomy sternal wound infection. Eur J Clin Microbiol Infect Dis 23, 419-421

Trülzsch, K., Hoffmann H, Keller, C., Schubert, S., Bader, L., Heesemann, J., Roggenkamp, A.
Highly resistant metabolically dwarf mutant of the E. coli complex is the cause of a chronic urinary tract infection. J Clin Microbiol 41, 5689-5694

Hoffmann H & Roggenkamp, A.
Population genetics of the nomenspecies Enterobacter cloacae. Appl Environmental Microbiol 69, 5306-5318

Hoffmann H, Bauerfeind, I.
High tissue egg burden mechanically impairing the tubal motility in gential schistosomiasis of the female. Acta Obst Gyn Scand. 82, 970-971

Roggenkamp, A., Ackermann, N., Jacobi, C.A., Truelzsch, K., Hoffmann H, Heesemann, J.
Molecular analysis of transport and oligomerization of the Yersinia enterocolitica adhesin YadA. J Bacteriol 185, 3735-3744

Roggenkamp, A., Hoffmann H.
Call for cooperation with population genetics in the nomenspecies Enterobacter cloacae. ESCMID News 1, 14

Hoffmann H, Esterre P, Ravaoalimalala VA, Ehrich JH, Doehring E.
Morbidity of schistosomiasis mansoni in the highlands of Madagascar and comparison of current sonographical classification systems. Trans R Soc Trop Med Hyg. 95 :623-629.

Hoffmann H, Hornef MW, Schubert S, Roggenkamp A.
Distribution of the outer membrane haem receptor protein ChuA in environmental and human isolates of Escherichia coli. Int J Med Microbiol. 291:227-230.

Hoffmann H, Esterre P., Ravaoalimalala V.A., Thomas A.K., Roux J., Seitz H.M., Doehring E.
In vivo and in vitro studies on the sonographical detection of Ascaris lumbricoides. Pediatric Radiol 27:226-229

Hoffmann H, Frenzel K., Doehring E.
Bilharziose  – Eine unvermeidliche Erkrankung? Deutsche Apotheker Zeitung (DAZ). 37:25-28

Hoffmann H, Esterre P., Ravaoalimalala V.A., Traoré M., Talla I., Ndugwa C.M., Gabone R., Kardorff R., Ehrich J.H.H., Doehring E.
Pourquoi comparer la morbidité de la bilharziose hépatosplénique dans six pays africains à l’aide de l’échographie? Présentation d’un projet OMS incluant Madagascar. Archives de l’Institut Pasteur de Madagascar. 61:37-42